Cardiolipin Stabilization & Mitochondrial Cristae Restoration
SS-31 (Elamipretide) — Mitochondria-Targeted Tetrapeptide
SS-31 (also known as Elamipretide or MTP-131) is a tetrapeptide that selectively concentrates in the inner mitochondrial membrane, where it binds cardiolipin — a phospholipid essential for electron transport chain function. By stabilizing cardiolipin and restoring cristae architecture, SS-31 improves mitochondrial efficiency, reduces ROS production, and has demonstrated cardioprotective effects in Phase II clinical trials for heart failure.
SS-31 is a 4-amino-acid tetrapeptide with an alternating aromatic-cationic motif (D-Arg-2',6'-Dmt-Lys-Phe-NH2). The dimethyltyrosine (Dmt) residue provides antioxidant activity, while the cationic residues (D-Arg, Lys) drive electrostatic concentration in the inner mitochondrial membrane, achieving 1,000-fold enrichment relative to cytoplasm.
SS-31 concentrates in the inner mitochondrial membrane via electrostatic interactions, where it binds cardiolipin — a phospholipid that anchors electron transport chain complexes. By stabilizing cardiolipin, SS-31 maintains optimal cristae architecture and ETC complex conformation, improving ATP synthesis efficiency and reducing electron leak (and consequent ROS generation).
SS-31 (Elamipretide) is a 4-amino-acid peptide that acts as a precision tool for mitochondrial repair, targeting cardiolipin in the inner mitochondrial membrane. It has completed Phase II clinical trials for heart failure and is in Phase III for Barth syndrome.
SS-31 concentrates 1,000-fold in the inner mitochondrial membrane, stabilizing cardiolipin and the electron transport chain complexes that produce ATP. This reduces ROS production, improves energy output, and protects against mitochondrial dysfunction.
Mitochondrial dysfunction is a hallmark of aging and a driver of heart failure and neurodegeneration. SS-31 concentrates at the exact site of ROS generation — a precision that conventional antioxidants lack.
SS-31 is a mitochondria-targeted tetrapeptide with Phase II/III clinical trial data for heart failure. Its cardiolipin-stabilizing mechanism and demonstrated ability to reverse age-related mitochondrial decline make it one of the most scientifically rigorous anti-aging research compounds available.
Binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure and maintaining optimal conformation of electron transport chain complexes for efficient ATP synthesis.
Reduces mitochondrial superoxide and hydrogen peroxide production by preventing electron leak from the electron transport chain.
Protects against ischemia-reperfusion injury by maintaining mitochondrial membrane potential and preventing mPTP opening during reperfusion.
Longevity Research
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| Peptide Class | Szeto-Schiller tetrapeptide (4 amino acids) |
| Molecular Weight | 639.8 Da |
| Regulatory Status | Phase II/III clinical trials (heart failure, Barth syndrome) |
| Available Sizes | 5mg, 10mg vials |
| Form | Lyophilized powder |
| Purity | ≥99% (third-party tested) |
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Purchase SS-31 at Purgo LabsMedical Disclaimer: All content on this site is for educational and research purposes only. Research peptides are not FDA-approved for human use. Always consult a qualified healthcare professional before considering any peptide or supplement protocol. Nothing on this site constitutes medical advice, diagnosis, or treatment.
