How Compound Review evaluates research peptides, grades evidence quality, and maintains editorial independence.
Compound Review is an independent reference guide for researchers, biohackers, and healthcare professionals who need accurate, mechanism-level information about research peptides. Our goal is to provide the most technically rigorous, evidence-graded peptide reference available on the open web — written at the level of a medical journal, not a supplement blog.
Every compound profile, comparison guide, and conditions page on this site is written by researchers with backgrounds in biochemistry, pharmacology, or clinical medicine. All content is reviewed against primary literature before publication and updated when new data emerges.
We rate the evidence quality for every compound and claim using a five-tier hierarchy based on study design and replication. This rating appears prominently in every compound profile and comparison guide.
Human RCT
Randomized controlled trials in humans. Highest evidence quality. Rare for research peptides — most are still in preclinical stages.
Human Cohort / Phase 1–2 Trial
Non-randomized human studies, Phase 1/2 trials, or observational cohort data. Strong signal but lower causal certainty than RCT.
Animal Model (In Vivo)
Rodent or other animal model studies. Extensive preclinical data exists for most peptides at this tier. Mechanism is well-established but human translation is uncertain.
In Vitro (Cell Culture)
Cell culture or isolated tissue studies. Useful for mechanism elucidation but does not establish in vivo efficacy.
Theoretical / Expert Opinion
Mechanistic extrapolation, expert opinion, or anecdotal reports. Used only to explain plausible mechanisms when direct evidence is absent.
All factual claims in compound profiles and comparison guides are sourced from peer-reviewed literature. We use the following source hierarchy:
| Source Type | Used For | Accepted |
|---|---|---|
| PubMed-indexed journals | Mechanism, efficacy, safety claims | Yes — primary source |
| ClinicalTrials.gov | Trial status, phase, enrollment | Yes — primary source |
| FDA / EMA databases | Regulatory status, approval history | Yes — primary source |
| Preprints (bioRxiv, medRxiv) | Emerging mechanisms only | With explicit caveat |
| Manufacturer / vendor claims | Never used for efficacy claims | No |
| Forum / anecdotal reports | Never used for efficacy claims | No |
Affiliate Disclosure
Compound Review earns affiliate commissions on qualifying purchases through Purgo Labs. This relationship is disclosed on every page that contains affiliate links. Affiliate relationships do not influence compound rankings, evidence ratings, or editorial content.
No Sponsored Rankings
Compound rankings in conditions guides and comparison pages are determined solely by evidence quality and mechanism relevance. No vendor pays for placement, ranking position, or editorial coverage.
No Paid Reviews
Compound Review does not accept payment for compound profiles, comparison guides, or conditions pages. All content is produced independently by our editorial team.
Vendor Independence
Our affiliate partner (Purgo Labs) has no editorial input into compound profiles, evidence ratings, or comparison guides. Negative findings, safety concerns, and evidence limitations are reported regardless of commercial relationships.
Peptide research moves quickly. We maintain the following update schedule to ensure content accuracy:
| Content Type | Review Frequency | Trigger for Immediate Update |
|---|---|---|
| Compound profiles | Quarterly | New Phase 2+ trial data, FDA action, significant safety signal |
| Comparison guides | Semi-annually | New head-to-head trial data, mechanism revision in primary literature |
| Conditions pages | Semi-annually | New systematic review or meta-analysis published |
| Dosage guides | Annually | New clinical dosing data, safety signal in published literature |
| Legal status pages | Quarterly | Regulatory action, scheduling change, FDA/EMA announcement |
All content on Compound Review is for educational and research purposes only. The compounds discussed on this site are not FDA-approved for the indications described. Nothing on this site constitutes medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before considering any peptide protocol. Research peptides are intended for laboratory research use only and are not intended for human consumption.
Medical Disclaimer: All content on this site is for educational and research purposes only. Research peptides are not FDA-approved for human use. Always consult a qualified healthcare professional before considering any peptide or supplement protocol. Nothing on this site constitutes medical advice, diagnosis, or treatment.