Compound Review is an independent reference guide for researchers, biohackers, and healthcare professionals who need accurate, mechanism-level information about research peptides. Every compound profile, comparison guide, and conditions page is written by researchers with backgrounds in biochemistry, pharmacology, or clinical medicine, and reviewed against primary literature before publication.
Affiliate Disclosure: Compound Review earns commissions from qualifying purchases through Purgo Labs. This relationship is disclosed on every page containing affiliate links. Affiliate revenue does not influence compound rankings, evidence ratings, or editorial content.
Evidence Grading System
We rate the evidence quality for every compound and claim using a five-tier hierarchy based on study design and replication. This rating appears prominently in every compound profile and comparison guide.
| Tier | Label | Description |
|---|
| Tier 1 | Human RCT | Randomized controlled trials in humans. Highest evidence quality. Rare for research peptides — most are still in preclinical stages. |
| Tier 2 | Human Cohort / Phase 1–2 Trial | Non-randomized human studies, open-label trials, and Phase 1–2 safety/efficacy data. Strong signal but lower certainty than RCT. |
| Tier 3 | Animal Model (In Vivo) | Rodent or other animal model studies. Extensive preclinical data exists for most peptides at this tier. Mechanism is well-established but human translation is uncertain. |
| Tier 4 | In Vitro (Cell Culture) | Cell culture and tissue studies. Useful for mechanism elucidation but limited translational value without in vivo confirmation. |
| Tier 5 | Theoretical / Expert Opinion | Mechanistic extrapolation, expert opinion, or anecdotal reports. Used only to explain plausible mechanisms when direct evidence is absent. |
Source Standards
All factual claims in compound profiles and comparison guides are sourced from peer-reviewed literature. Primary sources: PubMed-indexed journals (mechanism, efficacy, safety claims), ClinicalTrials.gov (trial status, phase, enrollment), FDA/EMA databases (regulatory status, approval history). Secondary sources used only to contextualize primary data, never as the sole citation for a factual claim. Anecdotal reports (forums, case studies) are labeled explicitly and never cited as evidence of efficacy.
Conflict of Interest Policy
Affiliate Commission Disclosure: Compound Review earns affiliate commissions on qualifying purchases through Purgo Labs. This relationship is disclosed on every page that contains affiliate links. Affiliate relationships do not influence compound rankings, evidence ratings, or editorial content.
No Paid Placement: Compound rankings in conditions guides and comparison pages are determined solely by evidence quality and mechanism relevance. No vendor pays for placement, ranking position, or editorial coverage.
Editorial Independence: Our affiliate partner (Purgo Labs) has no editorial input into compound profiles, evidence ratings, or comparison guides. Negative findings, safety concerns, and evidence limitations are reported regardless of commercial relationships.
Content Update Policy
Peptide research moves quickly. Compound profiles are reviewed when significant new research is published. Evidence tier ratings are updated when new human trial data becomes available. Regulatory status pages are reviewed quarterly. All pages display a last-updated date.