Complete Semaglutide dosage guide covering titration protocols, fat loss, and reconstitution for research use.
Semaglutide is a GLP-1 receptor agonist FDA-approved for type 2 diabetes (Ozempic) and weight management (Wegovy). It produces 10–15% body weight reduction in clinical trials and has the most extensive long-term safety data of any weight loss peptide.
Research Disclaimer: This dosage information is for educational and research purposes only. Semaglutide is not FDA-approved for human use (unless otherwise noted). Always consult a qualified healthcare professional before considering any peptide protocol.
| Protocol | Dose | Notes |
|---|---|---|
| Starting Dose | 0.25mg/week | Standard titration starting point. Run for 4 weeks before increasing. |
| Titration Schedule | Increase by 0.25mg every 4 weeks | 0.25 → 0.5 → 1.0 → 1.7 → 2.4mg/week. Standard FDA titration schedule. |
| Maintenance Dose | 1.0–2.4mg/week | Most people find 1.0–1.7mg/week provides significant fat loss with manageable side effects. |
Add bacteriostatic water per vial size. For a 5mg vial: add 2.5mL BAC water for 2mcg/μL concentration (0.5mg = 0.25mL = 25 units on a 100-unit syringe).
Once weekly injection on the same day each week. Can be taken with or without food.
Typically run continuously for 24–52 weeks for weight loss. Long-term maintenance dosing is common.
Lyophilized powder: refrigerate at 2–8°C. Reconstituted: refrigerate, use within 30 days.
Use our free peptide calculator to convert your Semaglutide dose into exact syringe units based on your vial concentration.
Start at 0.25mg/week for 4 weeks, then increase by 0.25mg every 4 weeks up to the maintenance dose of 1.0–2.4mg/week. Slow titration minimizes nausea and GI side effects.
Clinical trials show 10–15% body weight reduction at 68 weeks. Individual results vary significantly based on diet, exercise, and starting weight.
Both contain semaglutide. Ozempic is approved for type 2 diabetes (max 2mg/week dose). Wegovy is approved for weight management (max 2.4mg/week dose). The compounds are identical — only the approved indication and maximum dose differ.
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Visit Purgo LabsMedical Disclaimer: All content on this site is for educational and research purposes only. Research peptides are not FDA-approved for human use. Always consult a qualified healthcare professional before considering any peptide or supplement protocol. Nothing on this site constitutes medical advice, diagnosis, or treatment.