Important: The main human obesity trial of AOD-9604 did not meet its primary endpoint and was not published in a peer-reviewed journal; human fat-loss efficacy is not established.
Overview
AOD-9604 is a synthetic peptide fragment derived from the C-terminus of human growth hormone (hGH), specifically amino acids 176–191. Unlike full-length hGH, AOD-9604 retains the lipolytic (fat-burning) activity of the parent molecule without stimulating IGF-1 production or promoting cell proliferation. It received FDA GRAS designation in 2014 and has completed Phase II clinical trials for obesity (Phase 3 was not pursued; the Phase 2b trial did not meet its primary endpoint).
Mechanism of Action
AOD-9604 activates beta3-adrenergic receptors in adipose tissue, stimulating cAMP-mediated lipolysis and increasing fatty acid oxidation. Simultaneously, it suppresses acetyl-CoA carboxylase activity, reducing de novo lipogenesis and triglyceride synthesis. Unlike full-length hGH, it does not activate the JAK2/STAT5 pathway responsible for IGF-1 production.
Research Evidence
- FDA GRAS (Generally Recognized as Safe) designation granted in 2014
- Phase 2b obesity trial (METAOD-001, >500 subjects) did not meet its primary weight-loss endpoint; results were never published in a peer-reviewed journal
- No adverse effects on blood glucose, insulin sensitivity, or IGF-1 levels in clinical trials (clean safety profile)
- Stimulates lipolysis and inhibits lipogenesis through beta3-adrenergic receptor activation (preclinical data)
- FDA GRAS designation (2014) covers food safety only — not therapeutic efficacy
Bottom line: AOD-9604 is a GH-derived fat metabolism peptide with FDA GRAS status (food safety only) and a clean safety profile. Human fat-loss efficacy is not established — the Phase 2b obesity trial did not meet its primary endpoint and results were never published. It remains a tool for preclinical metabolic research.
Research Protocols & Dosage
Evidence-based research protocols, administration routes, and dosage considerations for AOD-9604 are detailed in the full compound profile. See also: Dosage guide for AOD-9604.
Sourcing & Quality
AOD-9604 is available from Purgo Labs with third-party COA verification and research-grade purity standards. View AOD-9604 at Purgo Labs.