Overview
Teduglutide (GLP-2 T) is a synthetic analog of glucagon-like peptide-2 (GLP-2), an intestinotrophic hormone produced by L-cells of the distal small intestine and colon. While GLP-1 and GLP-2 are both derived from the same proglucagon gene, they have entirely distinct receptor targets and physiological roles: GLP-2 acts specifically on the gastrointestinal tract to promote intestinal mucosal growth, enhance nutrient absorption, and maintain intestinal barrier integrity. Teduglutide is FDA-approved under the brand name Gattex® for the treatment of Short Bowel Syndrome (SBS) in adults and pediatric patients, making it one of the few research peptides in this catalog with full regulatory approval and extensive human clinical data.
Mechanism of Action
Teduglutide acts as a potent agonist of the GLP-2 receptor (GLP-2R), a G-protein coupled receptor expressed primarily on subepithelial myofibroblasts, enteric neurons, and enteroendocrine cells in the gastrointestinal tract. GLP-2R activation stimulates the Gαs/adenylyl cyclase/cAMP pathway, triggering downstream effects that include stimulation of intestinal crypt cell proliferation, inhibition of enterocyte apoptosis, and increased intestinal blood flow. The net effect is an increase in villus height and crypt depth — the structural determinants of intestinal absorptive capacity. Teduglutide also enhances intestinal barrier function by upregulating tight junction proteins, and may modulat
Research Evidence
- FDA-approved (Gattex®) for Short Bowel Syndrome — only approved GLP-2 analog
- Stimulates intestinal crypt cell proliferation and inhibits enterocyte apoptosis
- Increases villus height and crypt depth, enhancing intestinal absorptive surface area
- Reduces parenteral nutrition requirements in SBS patients in Phase III trials
- Enhances intestinal barrier function via tight junction protein upregulation
Bottom line: GLP-2 T (Teduglutide) is FDA-approved for short bowel syndrome, giving it one of the strongest clinical validation profiles in this catalog. The research-grade lyophilized powder supplied by Purgo Labs is for laboratory use only and differs from the clinical formulation. Its intestinotrophic mechanism makes it a key tool for gut biology research.
Research Protocols & Dosage
Evidence-based research protocols, administration routes, and dosage considerations for GLP-2 T are detailed in the full compound profile. See also: Dosage guide for GLP-2 T.
Sourcing & Quality
GLP-2 T is available from Purgo Labs with third-party COA verification and research-grade purity standards. View GLP-2 T at Purgo Labs.