The Definitive Peptide Research Reference Guide — Compound Review

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GHRH Analogs Research Hub

The complete reference for growth hormone-releasing hormone analogues — sermorelin, CJC-1295, and tesamorelin. Mechanism, half-life comparison, FDA status, dosing protocols, and stacking strategies.

What Is GHRH?

Growth hormone-releasing hormone (GHRH) is a 44-amino acid peptide produced by the hypothalamus that stimulates the anterior pituitary to synthesize and secrete growth hormone (GH). GHRH analogues mimic this signal with modified pharmacokinetics.

Shared Mechanism of Action

All GHRH analogues bind the GHRH receptor (GHRHR) on somatotroph cells in the anterior pituitary. This G-protein coupled receptor activates adenylyl cyclase, increasing intracellular cAMP and triggering GH synthesis and release.

GHRH Analogue Profiles

Sermorelin: Most Studied, shortest half-life (~10 min), preserves pulsatile GH release. CJC-1295: Longest Half-Life (6–8 days with DAC). Tesamorelin: FDA-Approved for HIV-associated lipodystrophy. Ipamorelin: Best Stack Partner (complementary GHS-R mechanism).