The Definitive Peptide Research Reference Guide — Compound Review

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Sermorelin vs Ipamorelin

Sermorelin vs Ipamorelin: GHRH analogue vs GHRP — two different receptor mechanisms for GH optimization. Sermorelin acts on GHRH receptors; Ipamorelin acts on ghrelin receptors. They are most effective when combined.

Mechanism Comparison

Sermorelin: binds GHRH receptors on pituitary somatotrophs, stimulating GH synthesis and secretion. Ipamorelin: binds ghrelin receptors (GHS-R1a), amplifying GH pulse amplitude. Different receptors, synergistic effect when combined.

Side Effect Comparison

Sermorelin: minimal side effects at research doses, occasional injection site reactions. Ipamorelin: most selective GHRP — does not significantly elevate cortisol or prolactin unlike GHRP-2 or GHRP-6. Both are well-tolerated.

Which to Choose

Sermorelin alone: when cost is a priority and pulsatile GH stimulation is sufficient. Ipamorelin alone: when GHRP-specific effects (appetite, GH pulse amplification) are the target. Combined: the standard protocol for maximum GH axis stimulation.