CJC-1295 vs Sermorelin: two GHRH analogues with different half-lives and GH pulse patterns. Sermorelin produces physiological pulsatile GH release; CJC-1295 with DAC produces sustained GH elevation.
Half-Life Comparison
Sermorelin: ~10–20 minutes half-life, produces sharp physiological GH pulses. CJC-1295 (no DAC): ~30 minutes, similar pulsatile pattern. CJC-1295 (with DAC): 6–8 days, produces sustained 'GH bleed' via albumin binding.
IGF-1 Elevation
Sermorelin: modest IGF-1 elevation, requires multiple daily injections for sustained effect. CJC-1295 with DAC: 200–400% IGF-1 elevation above baseline with weekly dosing in clinical studies. CJC-1295 is more potent for sustained IGF-1 elevation.
Which to Choose
Sermorelin: lower cost, physiological GH pulsatility, appropriate for anti-aging protocols where preserving natural GH rhythm is a priority. CJC-1295 with DAC: higher IGF-1 elevation, weekly dosing convenience, preferred when maximum GH axis stimulation is the goal.