The Definitive Peptide Research Reference Guide — Compound Review

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Peptides for Anti-Aging: Mechanisms, Evidence & Longevity Research

A mechanistic guide to 8 peptide compounds studied for longevity, cellular aging, immune senescence, and biological age reversal — grounded in the hallmarks of aging framework.

Aging Mechanisms These Compounds Target

Epithalon activates telomerase to elongate telomeres — the protective caps on chromosomes that shorten with each cell division and are a primary driver of cellular senescence. GHK-Cu modulates over 4,000 genes involved in tissue repair and antioxidant defense.

Compound Profiles

NAD+ supports sirtuin activation and mitochondrial biogenesis. MOTS-c activates AMPK signaling to mimic the metabolic effects of exercise. SS-31 stabilizes cardiolipin to protect mitochondrial membrane integrity.

Aging Hallmark Coverage

Summary of how each compound addresses key aging hallmarks from the López-Otín framework — including telomere attrition, mitochondrial dysfunction, cellular senescence, and deregulated nutrient sensing.