The Definitive Peptide Research Reference Guide — Compound Review

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MOTS-c vs NAD+

MOTS-c vs NAD+: two mitochondria-focused longevity compounds with complementary mechanisms. MOTS-c is a mitochondria-derived peptide; NAD+ is the rate-limiting coenzyme for sirtuin activation.

Mechanism Comparison

MOTS-c: activates AMPK, inhibits folate cycle, promotes glucose uptake in skeletal muscle, encoded in mitochondrial DNA. NAD+: sirtuin substrate, PARP substrate, central to electron transport chain, declines with age.

Research Applications

MOTS-c: metabolic research, insulin sensitivity, exercise performance. NAD+: sirtuin activation, DNA repair, energy metabolism, neurological research, anti-aging protocols.

Combination Protocol

MOTS-c and NAD+ target complementary mitochondrial pathways. MOTS-c: 5–10 mg subcutaneously 2–3x/week. NAD+: IV infusion 250–500 mg 1–2x/week or oral precursors (NMN/NR) 500–1000 mg/day.