The Definitive Peptide Research Reference Guide — Compound Review

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VIP Dosage Guide

VIP (Vasoactive Intestinal Peptide) is a 28-amino acid neuropeptide with potent anti-inflammatory, immunomodulatory, and vasodilatory effects. Research applications include autoimmune conditions, pulmonary hypertension, and gut motility disorders.

Standard Research Dosage

Inhaled: 100 mcg 4x daily (used in pulmonary hypertension research). Subcutaneous: 50–100 mcg per injection, 1–2x daily. Intravenous: 4 pmol/kg/min infusion in acute research settings.

Anti-Inflammatory Mechanism

VIP activates VPAC1 and VPAC2 receptors on immune cells, shifting the cytokine balance from pro-inflammatory (TNF-α, IL-6, IL-12) to anti-inflammatory (IL-10, TGF-β). It also promotes regulatory T cell differentiation.

Pulmonary Hypertension Research

Inhaled VIP reduces pulmonary vascular resistance and improves exercise capacity in pulmonary arterial hypertension. A Phase 2 trial showed significant hemodynamic improvement with 4x daily inhaled dosing.