Complete Tirzepatide dosage guide covering titration protocols, fat loss, and reconstitution for research use.
Tirzepatide is a dual GIP/GLP-1 receptor agonist FDA-approved for type 2 diabetes (Mounjaro) and weight management (Zepbound). It produces 15–22% body weight reduction in clinical trials — greater than semaglutide due to the added GIP receptor agonism.
Research Disclaimer: This dosage information is for educational and research purposes only. Tirzepatide is not FDA-approved for human use (unless otherwise noted). Always consult a qualified healthcare professional before considering any peptide protocol.
| Protocol | Dose | Notes |
|---|---|---|
| Starting Dose | 2.5mg/week | Standard titration starting point. Run for 4 weeks before increasing. |
| Titration Schedule | Increase by 2.5mg every 4 weeks | 2.5 → 5 → 7.5 → 10 → 12.5 → 15mg/week. Standard FDA titration schedule. |
| Maintenance Dose | 5–15mg/week | Most people find 5–10mg/week provides significant fat loss with manageable side effects. |
Add bacteriostatic water per vial size. For a 10mg vial: add 2mL BAC water for 5mcg/μL concentration (2.5mg = 0.5mL = 50 units on a 100-unit syringe).
Once weekly injection on the same day each week. Can be taken with or without food.
Typically run continuously for 24–72 weeks for weight loss. Long-term maintenance dosing is common.
Lyophilized powder: refrigerate at 2–8°C. Reconstituted: refrigerate, use within 30 days.
Use our free peptide calculator to convert your Tirzepatide dose into exact syringe units based on your vial concentration.
Start at 2.5mg/week for 4 weeks, then increase by 2.5mg every 4 weeks up to the maintenance dose of 5–15mg/week. Slow titration minimizes GI side effects.
Tirzepatide produces greater fat loss (15–22% vs 10–15% for semaglutide) due to the added GIP receptor agonism, which enhances fat cell insulin sensitivity and produces complementary appetite suppression.
The FDA-approved maximum dose is 15mg/week for both Mounjaro and Zepbound. Some research protocols use higher doses, but safety data above 15mg/week is limited.
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Visit Purgo LabsMedical Disclaimer: All content on this site is for educational and research purposes only. Research peptides are not FDA-approved for human use. Always consult a qualified healthcare professional before considering any peptide or supplement protocol. Nothing on this site constitutes medical advice, diagnosis, or treatment.