The Definitive Peptide Research Reference Guide — Compound Review

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Sermorelin Dosage Guide

Sermorelin is a synthetic analogue of the first 29 amino acids of GHRH (growth hormone-releasing hormone). It stimulates pituitary GH secretion and is the shortest GHRH fragment with full receptor binding activity.

Standard Research Dosage

Typical research doses range from 100–500 mcg per injection, administered subcutaneously. Most protocols use once-daily dosing before sleep to align with the natural GH pulse pattern.

Injection Timing

Evening administration (30–60 minutes before sleep) is standard because GH secretion peaks during slow-wave sleep. Morning administration is used in some protocols targeting daytime IGF-1 elevation.

Half-Life and Pulse Pattern

Sermorelin has a short half-life (~10–20 minutes), producing a physiological GH pulse rather than sustained elevation. This preserves the pulsatile GH secretion pattern and reduces the risk of pituitary desensitization compared to exogenous GH.