Complete Sermorelin dosage guide covering GH secretagogue protocols, timing, cycling, and reconstitution.
Sermorelin is a synthetic analog of the first 29 amino acids of growth hormone-releasing hormone (GHRH). It stimulates the pituitary to produce and release natural GH, making it one of the most physiological GH optimization approaches available.
Research Disclaimer: This dosage information is for educational and research purposes only. Sermorelin is not FDA-approved for human use (unless otherwise noted). Always consult a qualified healthcare professional before considering any peptide protocol.
| Protocol | Dose | Notes |
|---|---|---|
| Starting Dose | 100mcg/night | Conservative starting point. Assess tolerance and sleep quality response. |
| Standard Dose | 200–300mcg/night | Most commonly reported effective dose for sleep and recovery optimization. |
| High Dose | 500mcg/night | Used by some researchers for more aggressive GH optimization. Diminishing returns above 300mcg are common. |
Reconstitute with bacteriostatic water. For a 3mg vial: add 1.5mL BAC water for a concentration of 2mcg/μL (200mcg per 0.1mL/10 units).
Inject 30–45 minutes before bed on an empty stomach. Avoid carbohydrates for 2–3 hours prior — insulin blunts the GH response significantly.
Typically cycled 5 days on, 2 days off to prevent receptor desensitization. Some researchers run continuous protocols for 3–6 months.
Lyophilized powder: refrigerate at 2–8°C. Reconstituted: refrigerate, use within 20 days.
Use our free peptide calculator to convert your Sermorelin dose into exact syringe units based on your vial concentration.
200–300mcg injected 30–45 minutes before bed on an empty stomach is the most commonly reported effective dose for sleep quality improvement.
Insulin (released in response to carbohydrates) directly inhibits GH release. Taking Sermorelin in a fasted state ensures the pituitary can respond fully to the GHRH signal.
Most researchers report improved sleep quality within 1–3 weeks. The full benefit develops over 4–8 weeks as GH pulsatility is restored.
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Visit Purgo LabsMedical Disclaimer: All content on this site is for educational and research purposes only. Research peptides are not FDA-approved for human use. Always consult a qualified healthcare professional before considering any peptide or supplement protocol. Nothing on this site constitutes medical advice, diagnosis, or treatment.