Complete Retatrutide dosage guide covering titration protocols, fat loss, and reconstitution.
Retatrutide is a triple agonist targeting GIP, GLP-1, and glucagon receptors. It has shown the highest fat loss of any peptide in clinical trials (up to 24% body weight at 48 weeks). The glucagon component adds direct lipolytic activity beyond what GLP-1 alone provides.
Research Disclaimer: This dosage information is for educational and research purposes only. Retatrutide is not FDA-approved for human use (unless otherwise noted). Always consult a qualified healthcare professional before considering any peptide protocol.
| Protocol | Dose | Notes |
|---|---|---|
| Starting Dose | 0.5–1mg/week | Always start low regardless of prior GLP-1 experience. Receptor sensitivity does not carry over from tirzepatide or semaglutide. |
| Titration | Increase by 1–2mg every 4 weeks | Slow titration minimizes GI side effects. Do not rush to higher doses. |
| Target Dose | 4–12mg/week | Clinical trials used 4mg, 8mg, and 12mg doses. Most researchers find 4–6mg sufficient for significant fat loss. |
Add bacteriostatic water per vial size. For a 10mg vial: add 2mL BAC water for 5mcg/μL concentration (1mg = 0.2mL = 20 units on a 100-unit syringe).
Once weekly injection on the same day each week. Timing relative to meals is not critical.
Typically run continuously for 24–48 weeks for fat loss goals. Maintenance dosing after reaching target weight.
Lyophilized powder: refrigerate at 2–8°C. Reconstituted: refrigerate, use within 30 days.
Use our free peptide calculator to convert your Retatrutide dose into exact syringe units based on your vial concentration.
Always start at 0.5–1mg/week regardless of prior GLP-1 experience. Tirzepatide or semaglutide tolerance does not carry over — starting too high causes significant GI side effects.
Retatrutide produces greater fat loss (up to 24% vs 15–22% for tirzepatide) due to the added glucagon receptor agonism, which directly promotes lipolysis. It also tends to have more intense early side effects.
Most researchers report noticeable fat loss within 4–8 weeks of reaching an effective dose. Maximum fat loss is typically seen at 24–48 weeks.
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Visit Purgo LabsMedical Disclaimer: All content on this site is for educational and research purposes only. Research peptides are not FDA-approved for human use. Always consult a qualified healthcare professional before considering any peptide or supplement protocol. Nothing on this site constitutes medical advice, diagnosis, or treatment.