Complete PT-141 dosage guide covering sexual function protocols, timing, and reconstitution.
PT-141 (Bremelanotide) is a melanocortin receptor agonist that activates MC3R and MC4R in the central nervous system to produce sexual arousal. It is FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women and has robust clinical data in men with erectile dysfunction.
Research Disclaimer: This dosage information is for educational and research purposes only. PT-141 is not FDA-approved for human use (unless otherwise noted). Always consult a qualified healthcare professional before considering any peptide protocol.
| Protocol | Dose | Notes |
|---|---|---|
| Starting Dose | 0.5–1mg | Start low to assess tolerance. Nausea is the most common side effect at higher doses. |
| Standard Dose | 1–2mg | Most commonly reported effective dose. 1.75mg is the FDA-approved dose for women. |
| High Dose | 2–3mg | Higher doses increase efficacy but also nausea risk. Not recommended for new researchers. |
Add 2mL bacteriostatic water to a 10mg vial for a concentration of 5mcg/μL (1mg = 0.2mL = 20 units on a 100-unit syringe).
Inject 1–2 hours before desired activity. Effects typically onset within 1 hour and last 6–12 hours. Not for daily use — use as needed.
As-needed use rather than daily cycling. Most researchers limit use to 1–2 times per week maximum.
Lyophilized powder: refrigerate at 2–8°C. Reconstituted: refrigerate, use within 30 days.
Use our free peptide calculator to convert your PT-141 dose into exact syringe units based on your vial concentration.
Most researchers report onset within 1–2 hours of subQ injection. Effects typically last 6–12 hours.
PT-141 is a selective melanocortin agonist optimized for sexual function with a cleaner side effect profile. Melanotan II is less selective and produces tanning alongside sexual effects.
Yes — PT-141 (as Vyleesi) is FDA-approved for hypoactive sexual desire disorder in premenopausal women. It works through a central neurological mechanism that applies to both sexes.
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Visit Purgo LabsMedical Disclaimer: All content on this site is for educational and research purposes only. Research peptides are not FDA-approved for human use. Always consult a qualified healthcare professional before considering any peptide or supplement protocol. Nothing on this site constitutes medical advice, diagnosis, or treatment.