Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland peptide Epithalamin. Research focuses on telomere elongation, anti-aging effects, and circadian rhythm regulation.
Standard Research Dosage
5–10 mg per day, administered subcutaneously or intravenously for 10–20 day cycles. The most studied protocol is 10 mg/day × 10 days, repeated 2x per year. Some protocols use 5 mg/day × 20 days.
Telomere Research
Epithalon activates telomerase in human somatic cells in vitro, extending telomere length. Animal studies show lifespan extension of 13–24% in mice. Human data is limited to observational studies from Russian research groups.
Circadian and Melatonin Effects
Small studies from Khavinson's group suggest Epithalon may influence melatonin secretion in elderly subjects. These findings have not been replicated in independent randomized controlled trials. All circadian and melatonin claims require independent confirmation before clinical conclusions can be drawn.