What is the standard Epithalon dosage?

The most commonly reported research protocol is 5–10 mg per day for 10–20 consecutive days, administered as a single daily subcutaneous or intravenous injection. This 'course' protocol is repeated 1–2 times per year. Some researchers use 5 mg every other day for 20 days as an alternative schedule.

How does Epithalon work?

Epithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) that activates telomerase — the enzyme that rebuilds telomere length. It also regulates the pineal gland's melatonin production and has demonstrated antioxidant, anti-tumor, and immunomodulatory effects in preclinical research.

What are the reported benefits of Epithalon?

Preclinical research shows Epithalon extends telomere length, restores melatonin production in aging subjects, reduces oxidative stress markers, improves immune function, and extended lifespan by 24% in animal models. Human studies are limited but suggest improvements in sleep quality and hormonal regulation.

What are the side effects of Epithalon?

Epithalon has a favorable safety profile in preclinical studies with no significant toxicity observed. The most commonly reported effects in research contexts are mild injection site reactions and transient fatigue. No serious adverse events have been reported at standard research doses.

How does Epithalon compare to other longevity peptides?

Epithalon targets telomere length and pineal function — distinct from MOTS-c (mitochondrial AMPK activation), SS-31 (mitochondrial membrane protection), and Thymosin Alpha-1 (immune modulation). Many longevity researchers stack Epithalon with MOTS-c and SS-31 for complementary anti-aging mechanisms.

Can Epithalon be combined with NAD+ precursors?

Yes — Epithalon and NAD+ precursors (NMN, NR) work through complementary longevity pathways. Epithalon activates telomerase and regulates the pineal gland, while NAD+ precursors support sirtuin activity and mitochondrial function. The combination is popular in comprehensive longevity protocols.

Is Epithalon legal to buy for research?

Epithalon is legal to purchase for research purposes in the United States, Canada, and most of Europe. It is not FDA-approved for human use and is sold strictly as a research chemical. It is not currently on WADA's prohibited list for competitive sports.

How should Epithalon be stored?

Lyophilized Epithalon should be stored at −20°C (freezer) for long-term storage or at 2–8°C (refrigerator) for up to 3 months. Once reconstituted with bacteriostatic water, store refrigerated and use within 30 days. Protect from light and avoid repeated freeze-thaw cycles.

Dosage Reference

Epithalon Dosage Guide

Complete Epithalon dosage guide covering longevity protocols, telomerase activation, and cycling.

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Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland peptide Epithalamin. It activates telomerase, extends telomere length, and has shown anti-aging effects in multiple animal models and Russian clinical research.

Research Disclaimer: This dosage information is for educational and research purposes only. Epithalon is not FDA-approved for human use (unless otherwise noted). Always consult a qualified healthcare professional before considering any peptide protocol.

Epithalon Dosage Reference

Protocol	Dose	Notes
Standard Cycle Dose	5–10mg/day	Run for 10–20 days per cycle, 2–3 times per year.
Low Dose Maintenance	2–5mg/day	Some researchers use lower doses for longer continuous periods.
High Dose Protocol	10mg/day	Used in some Russian clinical protocols. 10mg/day for 10 days = 100mg total per cycle.

Reconstitution

Add 1mL bacteriostatic water to a 10mg vial for a concentration of 10mcg/μL (5mg = 0.5mL = 50 units on a 100-unit syringe).

Timing

Morning or evening injection. Timing relative to meals is not critical. Some researchers prefer evening to align with pineal gland activity.

Cycle Length

10–20 day cycles, 2–3 times per year. This is the most common longevity protocol. Continuous daily use is not standard.

Storage

Lyophilized powder: refrigerate at 2–8°C. Reconstituted: refrigerate, use within 30 days.

Calculate Your Exact Draw Volume

Use our free peptide calculator to convert your Epithalon dose into exact syringe units based on your vial concentration.

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Frequently Asked Questions

How often should I cycle Epithalon?

The standard protocol is 10–20 day cycles, 2–3 times per year. This matches the Russian clinical research protocols that showed the most significant anti-aging effects.

How does Epithalon extend lifespan?

Epithalon activates telomerase, which maintains telomere length. Telomere shortening is a primary driver of cellular aging — as telomeres shorten, cells lose the ability to divide and eventually become senescent.

Is Epithalon safe for long-term use?

Available research, primarily from Russian clinical studies, suggests Epithalon has a favorable safety profile. Long-term human data beyond clinical trial settings is limited.

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Medical Disclaimer: All content on this site is for educational and research purposes only. Research peptides are not FDA-approved for human use. Always consult a qualified healthcare professional before considering any peptide or supplement protocol. Nothing on this site constitutes medical advice, diagnosis, or treatment.

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