The Definitive Peptide Research Reference Guide — Compound Review

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DSIP Dosage Guide

DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide that modulates sleep architecture, particularly slow-wave sleep. Research applications include sleep quality improvement, stress response modulation, and opiate withdrawal.

Standard Research Dosage

25–50 mcg/kg body weight, administered subcutaneously or intravenously. For a 75 kg subject, this corresponds to approximately 2–4 mg per injection. Timing: 30–60 minutes before intended sleep.

Sleep Architecture Effects

DSIP increases slow-wave sleep (SWS) duration and reduces sleep onset latency in research subjects. It appears to act on hypothalamic sleep-regulating circuits rather than directly inducing sedation.

Stress and Cortisol Research

DSIP modulates the HPA axis, reducing stress-induced cortisol elevation. Animal studies show DSIP reduces stress-related behaviors and normalizes disrupted circadian rhythms.