NAD+ vs Glutathione: two foundational cellular health compounds. NAD+ drives energy metabolism and sirtuin activation; Glutathione is the primary intracellular antioxidant and detoxification cofactor.
Mechanism Comparison
NAD+: electron carrier in glycolysis and TCA cycle, substrate for SIRT1-7 and PARP enzymes, declines ~50% between ages 40–60. Glutathione: neutralizes ROS via glutathione peroxidase, regenerates vitamins C and E, supports Phase II liver detoxification.
IV Protocol Comparison
NAD+: 250–1000 mg IV over 2–4 hours, 1–5x/week. Glutathione: 600–1200 mg IV push or in saline, 1–3x/week. Both are commonly administered together in longevity IV protocols.
Which to Prioritize
NAD+: when energy metabolism, cognitive function, or sirtuin activation is the primary endpoint. Glutathione: when oxidative stress, liver health, or detoxification is the primary endpoint. Most longevity protocols include both.