Master Immunomodulatory Neuropeptide & Circadian Rhythm Regulator
VIP — Vasoactive Intestinal Peptide
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide produced throughout the nervous system, gut, and immune cells. It exerts potent anti-inflammatory effects by suppressing pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12) and promoting regulatory T-cell differentiation. An inhaled form (Aviptadil) is FDA-approved for pulmonary hypertension.
VIP is a 28-amino-acid neuropeptide (3,326.8 Da) belonging to the secretin/glucagon superfamily. It is produced by neurons in the enteric nervous system, hypothalamus, and throughout the peripheral nervous system, as well as by immune cells including T-cells and mast cells.
VIP binds VPAC1 and VPAC2 G-protein coupled receptors, activating adenylyl cyclase and elevating intracellular cAMP. This activates PKA, which phosphorylates and inhibits NF-kB — the master transcription factor for pro-inflammatory cytokine production. VIP also promotes Foxp3+ regulatory T-cell differentiation and tolerogenic dendritic cell polarization.
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide that acts as a master anti-inflammatory signal throughout the nervous system, gut, and immune system. An inhaled form (Aviptadil) is FDA-approved for pulmonary hypertension.
VIP binds VPAC receptors on immune cells, suppressing the NF-kB inflammatory cascade and blocking production of TNF-alpha, IL-6, and other pro-inflammatory cytokines. It also promotes regulatory T-cells and regulates circadian rhythms.
Chronic inflammation drives autoimmune disease, cardiovascular disease, and neurodegeneration. VIP suppresses the NF-kB pathway while promoting immune tolerance — a uniquely powerful combination for inflammation research.
VIP is a pleiotropic neuropeptide with FDA approval (inhaled), Phase II/III clinical trial data for ARDS and COVID-19, and a well-characterized mechanism for suppressing chronic inflammation.
Binds VPAC1 and VPAC2 G-protein coupled receptors, activating adenylyl cyclase and elevating intracellular cAMP — the primary mechanism for its anti-inflammatory and immunomodulatory effects.
Inhibits NF-kB activation in macrophages and dendritic cells, suppressing TNF-alpha, IL-6, IL-12, and IFN-gamma production.
Promotes the differentiation of Foxp3+ regulatory T-cells (Tregs) and tolerogenic dendritic cells, shifting immune responses toward tolerance.
Immune Research
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| Peptide Class | Neuropeptide/immunomodulator (28 amino acids) |
| Molecular Weight | 3,326.8 Da |
| Regulatory Status | FDA-approved inhaled (pulmonary hypertension); research chemical (injectable) |
| Available Sizes | 2mg, 5mg vials |
| Form | Lyophilized powder |
| Purity | ≥99% (third-party tested) |
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Purchase VIP at Purgo LabsMedical Disclaimer: All content on this site is for educational and research purposes only. Research peptides are not FDA-approved for human use. Always consult a qualified healthcare professional before considering any peptide or supplement protocol. Nothing on this site constitutes medical advice, diagnosis, or treatment.
