Human data exist for the pharmaceutical form (aviptadil) — its effects are the predictable results of a potent vasodilator
VIP is an endogenous 28-amino-acid neuropeptide with strong vasodilatory, bronchodilatory and immunomodulatory actions. A pharmaceutical form, aviptadil, has been used in combination with phentolamine for erectile dysfunction in some countries and was studied by intravenous infusion in COVID-19 respiratory failure. The adverse-effect profile follows the pharmacology: it lowers blood pressure and raises heart rate.
Research-use information only. Research-grade VIP is not an approved medicine; where trial or label figures appear below they belong to the pharmaceutical product studied, not to any research vial. This page does not give dosing or medical advice.
Every rate carries its source. Where no source exists, no rate is printed.
| Effect | Rate (sourced) | Detail | Source |
|---|---|---|---|
| Hypotension, flushing, tachycardia | not quantified | Direct consequences of VIP-receptor-mediated vasodilation; reported with intravenous aviptadil and expected with systemic exposure. | Delgado et al. 2004 (review of VIP pharmacology) |
| Diarrhoea | not quantified | VIP stimulates intestinal secretion — the mechanism of the diarrhoea seen with VIP-secreting tumours (VIPoma). | Delgado et al. 2004 |
| Injection-site reactions | not quantified | Expected for any injected peptide; unquantified. | General |
Regulatory status: Aviptadil/phentolamine (Invicorp) is approved for erectile dysfunction in some European countries; VIP is not approved in the US. Research-grade VIP is not the approved product.
Everything above describes VIP the molecule. The risk specific to a research vial is different: it may not contain VIP at the labelled amount, and it may contain what the synthesis left behind. Identity (mass spectrometry), purity (HPLC), measured net content and an endotoxin result are the four lines on a certificate that bear on adverse effects, and only a certificate you can check at the laboratory tells you any of them. This is what we have verified for VIP so far.
4 of the 77 vendors on our scoreboard list VIP with a price we read on the product page (23 Sept 2026–23 Sept 2026). Of those, 4 name their testing laboratory, 4 publish certificates that resolve on the lab's own site, and 4 publish measured milligrams against the label. The full ranking, with every dated price, is on Best VIP Vendors.
| Vendor | Rubric | Lab named | Price read |
|---|---|---|---|
| Peptide Giantspartner | 10/10 | Janoshik Analytical · Vanguard Laboratory | $49.99 · 10mg · 23 Sept 2026 |
| Purgo Labspartner | 10/10 | SteriGenix · Freedom Diagnostics | $47.99 · 10mg · 23 Sept 2026 |
| PS Peptidespartner | 8/10 | North American Diagnostics | $74.99 · 5mg · 23 Sept 2026 |
| Puratek Peptidespartner | 7/10 | ILS Laboratories (on certificates) · page credits Freedom Diagnostics | $53.95 · 10mg · 23 Sept 2026 |
None yet for VIP specifically. The COA library holds the certificates we have read for each vendor on other compounds, which is the next best signal of how that vendor documents a lot.
Mostly what a strong vasodilator does: a drop in blood pressure, flushing and a faster heart rate, plus loose stools because VIP drives intestinal secretion. Those are pharmacology, seen with the aviptadil product; there are no rates for subcutaneous research-grade VIP.