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No human trial data

DSIP Side Effects

Small human studies from the late 1970s–1980s; no modern controlled trial and no systematic adverse-event data

Delta sleep-inducing peptide was isolated from rabbit brain in 1977 and studied in humans through the 1980s for insomnia and withdrawal states, in small trials that a 2006 review called inconclusive. None of that work recorded adverse effects systematically, and there has been no controlled trial since. What follows is what the literature contains — which is very little.

Research-use information only. Research-grade DSIP is not an approved medicine; where trial or label figures appear below they belong to the pharmaceutical product studied, not to any research vial. This page does not give dosing or medical advice.

What is reported

Every rate carries its source. Where no source exists, no rate is printed.

EffectRate (sourced)DetailSource
Adverse effects in the early human studiesnot quantifiedNot systematically recorded; reports describe the peptide as well tolerated without giving numbers.Kovalzon 2006 (review)
Injection-site reactionsnot quantifiedExpected for any injected peptide; unquantified for DSIP.General

What is not known

  • •Any adverse-effect rate.
  • •Whether DSIP does anything reproducible in humans — the 2006 review titled it 'a still unresolved riddle'.
  • •Identity and dose of any research vial.

Mechanism-based cautions

  • •DSIP has been reported to modulate stress-axis hormones (ACTH, cortisol) in animal work; effects on endocrine measurements are plausible and unmeasured in humans.
  • •Sedation is the intended effect in the sleep hypothesis; combining with other sedatives has never been studied.

Regulatory status: Not approved anywhere.

References

  1. Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proceedings of the National Academy of Sciences USA, 1977. PMID 265572.
  2. Graf MV, Kastin AJ. Delta-sleep-inducing peptide (DSIP): a review. Neuroscience & Biobehavioral Reviews, 1984. PMID 6145137.
  3. Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. Journal of Neurochemistry, 2006. PMID 16539679.

What is actually in a research vial

Everything above describes DSIP the molecule. The risk specific to a research vial is different: it may not contain DSIP at the labelled amount, and it may contain what the synthesis left behind. Identity (mass spectrometry), purity (HPLC), measured net content and an endotoxin result are the four lines on a certificate that bear on adverse effects, and only a certificate you can check at the laboratory tells you any of them. This is what we have verified for DSIP so far.

Who sells DSIP, and what they document

9 of the 77 vendors on our scoreboard list DSIP with a price we read on the product page (23 Sept 2026–23 Sept 2026). Of those, 9 name their testing laboratory, 6 publish certificates that resolve on the lab's own site, and 8 publish measured milligrams against the label. The full ranking, with every dated price, is on Best DSIP Vendors.

VendorRubricLab namedPrice read
Peptide Giantspartner10/10Janoshik Analytical · Vanguard Laboratory$21.99 · 5mg · 23 Sept 2026
Purgo Labspartner10/10SteriGenix · Freedom Diagnostics$35.99 · 10mg · 23 Sept 2026
Ameano Peptidespartner9/10Janoshik Analytical$58.00 · 10mg · 23 Sept 2026
Everest Peptides8/10Freedom Diagnostics$26.24 · 5mg · 23 Sept 2026
PS Peptidespartner8/10North American Diagnostics$39.99 · 5mg · 23 Sept 2026

Top 5 by rubric score; 4 more on the ranking page.

DSIP certificates we have opened

None yet for DSIP specifically. The COA library holds the certificates we have read for each vendor on other compounds, which is the next best signal of how that vendor documents a lot.

Frequently asked

Is DSIP safe?

Unknown in the way that word is normally used. Early small human studies reported no obvious harm but did not measure adverse effects systematically, and nothing controlled has been done since. Absence of data is not evidence of safety.