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Human trial data

CJC-1295 Side Effects

Small human pharmacology studies exist (healthy volunteers, 2006); development was discontinued — no approval

CJC-1295 with DAC was studied in healthy adults in single- and multiple-dose pharmacokinetic trials that reported injection-site reactions, headache, diarrhoea and flushing, with sustained GH and IGF-1 elevation for days after a dose. The compound never reached approval. Long-term safety of sustained GH elevation is the open question.

Research-use information only. Research-grade CJC-1295 is not an approved medicine; where trial or label figures appear below they belong to the pharmaceutical product studied, not to any research vial. This page does not give dosing or medical advice.

What is reported

Every rate carries its source. Where no source exists, no rate is printed.

EffectRate (sourced)DetailSource
Injection-site reactions, headache, diarrhoea, flushingnot quantifiedReported in the phase 1 programme; mostly mild and transient.Teichman et al. 2006
Sustained GH and IGF-1 elevationnot quantifiedIGF-1 stayed elevated for up to 28 days after multiple doses — the pharmacology, and the reason long-term concerns exist.Teichman et al. 2006

What is not known

  • •Long-term effects of continuously elevated GH/IGF-1 — the trials were short.
  • •Research-grade identity (DAC vs no-DAC) and dose.

Mechanism-based cautions

  • •GH/IGF-1 axis: theoretical concern with active malignancy; possible glucose intolerance and fluid retention.
  • •The 'no DAC' form sold by most vendors is pharmacologically a different, short-acting molecule (modified GRF 1-29).

Regulatory status: Not approved anywhere; development discontinued in the late 2000s.

References

  1. Teichman SL, et al. Prolonged stimulation of growth hormone and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GHRH, in healthy adults. Journal of Clinical Endocrinology & Metabolism, 2006. PMID 16352683.

What is actually in a research vial

Everything above describes CJC-1295 the molecule. The risk specific to a research vial is different: it may not contain CJC-1295 at the labelled amount, and it may contain what the synthesis left behind. Identity (mass spectrometry), purity (HPLC), measured net content and an endotoxin result are the four lines on a certificate that bear on adverse effects, and only a certificate you can check at the laboratory tells you any of them. This is what we have verified for CJC-1295 so far.

Who sells CJC-1295, and what they document

7 of the 77 vendors on our scoreboard list CJC-1295 with a price we read on the product page (23 Sept 2026–23 Sept 2026). Of those, 7 name their testing laboratory, 6 publish certificates that resolve on the lab's own site, and 7 publish measured milligrams against the label. The full ranking, with every dated price, is on Best CJC-1295 Vendors.

VendorRubricLab namedPrice read
Peptide Giantspartner10/10Janoshik Analytical · Vanguard Laboratory$45.00 · 5mg · 23 Sept 2026
Purgo Labspartner10/10SteriGenix · Freedom Diagnostics$43.99 · 10mg · 23 Sept 2026
Ameano Peptidespartner9/10Janoshik Analytical$38.00 · 5mg · 23 Sept 2026
TrustedPepspartner9/10Freedom Diagnostics (on certificates)$30.00 · 10mg · 23 Sept 2026
PS Peptidespartner8/10North American Diagnostics$35.99 · 5mg · 23 Sept 2026

Top 5 by rubric score; 2 more on the ranking page.

CJC-1295 certificates we have opened

None yet for CJC-1295 specifically. The COA library holds the certificates we have read for each vendor on other compounds, which is the next best signal of how that vendor documents a lot.

Frequently asked

What is the difference between CJC-1295 DAC and no-DAC for side effects?

DAC extends the half-life to days, so GH/IGF-1 stay elevated continuously; no-DAC (Mod GRF 1-29) acts for minutes and produces a pulse. Continuous elevation is the profile with more theoretical long-term concern.