Semaglutide titration schedule: step-by-step dose escalation protocol for GLP-1 research applications.
Standard Titration Schedule
The FDA-approved Wegovy titration protocol follows 4-week intervals at each dose level. The 0.25 mg starting dose is intentionally sub-therapeutic — it does not produce meaningful weight loss, but is critical for GI adaptation before escalating to th
Slow Titration Protocol
The STEP (Semaglutide Treatment Effect in People with Obesity) trial program enrolled over 4,500 participants across five pivotal trials, establishing the efficacy and safety profile of the standard titration schedule.
Standard vs Slow Titration: Which Is Right?
The FDA-approved Wegovy titration protocol follows 4-week intervals at each dose level. The 0.25 mg starting dose is intentionally sub-therapeutic — it does not produce meaningful weight loss, but is critical for GI adaptation before escalating to th