The Definitive Peptide Research Reference Guide — Compound Review

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GHRP Peptides Dosage Hub

GHRP (Growth Hormone Releasing Peptide) overview: comparison of Ipamorelin, GHRP-2, and GHRP-6 — selectivity profiles, GH pulse amplitudes, and side effect considerations.

GHRP Comparison

Ipamorelin: most selective, minimal cortisol/prolactin elevation, moderate GH pulse. GHRP-2: stronger GH pulse, moderate cortisol elevation. GHRP-6: strongest GH pulse, significant appetite stimulation and cortisol elevation.

Mechanism of Action

GHRPs bind the ghrelin receptor (GHS-R1a) on pituitary somatotrophs and hypothalamic neurons, amplifying GH pulse amplitude. They work synergistically with GHRH analogues by acting on a different receptor.

Dosage Reference

Ipamorelin: 200–300 mcg/injection. GHRP-2: 100–200 mcg/injection. GHRP-6: 100–200 mcg/injection. All administered subcutaneously 2–3x daily. Combination with GHRH analogue is standard practice.