The Definitive Peptide Research Reference Guide — Compound Review

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GHRH Analogues Dosage Hub

GHRH analogues overview: comparison of Sermorelin, CJC-1295, and Tesamorelin — their half-lives, GH pulse patterns, and appropriate research applications.

GHRH Analogue Comparison

Sermorelin: half-life ~10 min, pulsatile GH pattern, lowest cost. CJC-1295 (no DAC): half-life ~30 min, pulsatile, typically combined with GHRP. CJC-1295 (DAC): half-life 6–8 days, sustained GH elevation. Tesamorelin: half-life ~26 min, FDA-validated, highest clinical evidence.

Choosing the Right Analogue

For pulsatile GH research: Sermorelin or CJC-1295 (no DAC) + GHRP. For sustained IGF-1 elevation: CJC-1295 with DAC. For highest clinical evidence base: Tesamorelin. For cost-effectiveness: Sermorelin.

Receptor Mechanism

All GHRH analogues bind the GHRH receptor (GHRHR) on somatotroph cells in the anterior pituitary, stimulating GH synthesis and secretion. The key variable is half-life, which determines whether GH release is pulsatile or sustained.