The Definitive Peptide Research Reference Guide — Compound Review

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Semax vs Selank

Semax vs Selank: two Russian-developed intranasal nootropic peptides with complementary CNS effects. Semax is primarily cognitive-enhancing and neuroprotective; Selank is primarily anxiolytic with nootropic properties.

Mechanism Comparison

Semax: ACTH(4-7) analogue with Pro-Gly-Pro extension, upregulates BDNF and NGF, neuroprotective, approved in Russia for stroke treatment. Selank: tuftsin analogue, modulates IL-6 and serotonin/dopamine systems, anxiolytic.

Research Applications

Semax: cognitive enhancement, neuroprotection, BDNF upregulation, stroke recovery. Selank: anxiety reduction, stress modulation, immune modulation (tuftsin component), mild nootropic effects.

Combination Protocol

Semax and Selank are sometimes combined for complementary CNS effects. Semax: 200–600 mcg intranasally 1–2x daily. Selank: 250–500 mcg intranasally 1–2x daily. The combination targets both cognitive enhancement (Semax) and anxiety reduction (Selank).