Three-way GHRP comparison: Ipamorelin, GHRP-2, and GHRP-6 — selectivity profiles, GH pulse amplitudes, side effects, and which is appropriate for different research applications.
Selectivity Comparison
Ipamorelin: most selective — GH release only, minimal cortisol/prolactin elevation. GHRP-2: moderate selectivity — stronger GH pulse but moderate cortisol elevation. GHRP-6: least selective — strongest GH pulse, significant appetite stimulation and cortisol elevation.
GH Pulse Amplitude
GHRP-6 produces the strongest GH pulse at equivalent doses, followed by GHRP-2, then Ipamorelin. However, Ipamorelin's selectivity makes it the preferred choice when minimizing cortisol elevation is a priority.
Which to Choose
Ipamorelin: preferred for most research protocols due to selectivity and tolerability. GHRP-2: when stronger GH pulse is needed and moderate cortisol elevation is acceptable. GHRP-6: when appetite stimulation is a desired research endpoint alongside GH release.